Chromogranin A in cardiovascular endocrinology

The surging role of Chromogranin A in cardiovascular homeostasis

Together with Chromogranin B and Secretogranins, Chromogranin A (CGA) is stored in secretory (chromaffin) granules of the diffuse neuroendocrine system and released with noradrenalin and adrenalin. Co-stored within the granule together with neuropeptideY, cardiac natriuretic peptide hormones, several prohormones and their proteolytic enzymes, CGA is a multifunctional protein and a major marker ...

CARDIOVASCULAR ENDOCRINOLOGY Endogenous Sex Hormones and Cardiovascular Disease in Men

Potential roles of ROR-α in cardiovascular endocrinology

Atherosclerosis is a chronic disease of the arteries whose development involves a local inflammatory response characterized by the activation of different cells such as macrophages, T-lymphocytes, smooth muscle cells (SMCs) and endothelial cells (ECs). This review will summarize recent evidence for a modulatory role of the nuclear receptor ROR-alpha in cardiovascular disease.

Chromogranin A in heart failure.

Since the initial demonstration of increased circulating norepinephrine in patients with chronic heart failure, a large number of investigations on neuroendocrine activation in heart failure have followed. It is now clear that persistent activation of neuroendocrine systems, notably the adrenergic system and the renin–angiotensin system is maladaptive in heart failure (reviewed in). In this iss...

Chromogranin A (CgA) References

"There appears to be a direct correlation between tumor burden and serum CgA levels. Rising serum levels of CgA can predeed radiographic evidence of recurrence. . . . .Using serum CgA level above 30 U/ml, one is able to discriminate between disease free patients and those with recurrent metastatic disease with a sensitivity of 92% and specificity of 96%. This is superior to measuring urinary 5-...